Revolutionizing Daptomycin Dosing: A Single 7-11 Hour Sample for Pragmatic Application

Jacopo Angelini; Shuhan Liu; Simone Guiliano; Sarah Flammini; Luca Martini; Carlo Tascini; Massimo Baraldo; Manjunath P Pai

doi:10.1093/cid/ciae178

Revolutionizing Daptomycin Dosing: A Single 7-11 Hour Sample for Pragmatic Application

Clin Infect Dis. 2024 Mar 29:ciae178. doi: 10.1093/cid/ciae178. Online ahead of print.

Authors

Jacopo Angelini^{1

2}, Shuhan Liu³, Simone Guiliano⁴, Sarah Flammini⁴, Luca Martini⁴, Carlo Tascini⁴, Massimo Baraldo^{1

2}, Manjunath P Pai³

Affiliations

¹ Clinical Pharmacology and Toxicology Institute, University Hospital Friuli Centrale ASUFC, 33100 Udine, Italy.
² Department of Medicine (DMED), University of Udine (UNIUD), 33100 Udine, Italy.
³ Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.
⁴ Infectious Diseases Division, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.

PMID: 38552199
DOI: 10.1093/cid/ciae178

Abstract

Precision daptomycin dosing faces clinical implementation barriers despite known exposure-safety concerns with the use of twice the regulatory-approved doses. We propose achieving a single 7-11 hour post-dose plasma target concentration of 30 mg/L to 43 mg/L to be a practical starting point to facilitate precision daptomycin dosing.

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